Abstract:
Model-informed precision dosing (MIPD) software leverages pharmacokinetic (PK) and pharmacodynamic (PD) models to optimize individualized medication dosing. By integrating patient-specific data such as demographics, laboratory measurements and clinical parameters with advanced mathematical models, MIPD tools provide tailored dosing recommendations for safe and effective therapy in real-time. MIPD represents a transformative approach in precision medicine, bridging clinical practice with quantitative pharmacology for more personalized and effective care. After the presentations, the audience will be familiar with the underlying concept of MIPD, have seen case examples, and were introduced to some challenges when using MIPD software.
Prof. Sebastian Wicha, University of Hamburg, Germany
Sebastian Wicha is a tenured Full Professor of Clinical Pharmacy. He is leading the research group Clinical Pharmacy at the Institute of Pharmacy, University of Hamburg, Germany since 2017. He is a pharmacist by training holding a Ph.D. in Clinical Pharmacy from the Freie Universität Berlin, Germany (2015) and gained experience as a postdoctoral researcher at the Pharmacometrics Research Group at Uppsala University, Sweden (2015-2017). His research group aims to improve and individualize drug therapy by means of pharmacokinetic-pharmacodynamic and pharmacometric techniques with a special focus on anti-infectives. In this field, he has published >100 peer-reviewed papers. His research group has expertise in bioanalysis, pharmacometric data analysis, and develops open-access web-based software to foster model-informed precision dosing (TDMx.eu). Sebastian is the currently the chairperson of the PK/PD study group of the European Society for Clinical Microbiology and Infectious Diseases (ESCMID). Moreover, he is an external expert for pharmacometrics for the German Federal Institute for Drugs and Medical Devices (BfArM) and the European Medicines Agency (EMA).
Ron Keizer, InsightRx, San Francisco, California, USA
Ron is a pharmacometrician, pharmacist, and software engineer with a passion for developing tools to improve drug dosing in patients. He has held various academic positions and authored several commercial and open source softwares in the pharmacometrics field. He is the co-founder and Chief Scientist of InsightRX, a San Francisco based company developing precision dosing software for providers and pharma.